Link between Nephrogenic Systemic Fibrosis and Gadolinium

An article in the current issue of the New England Journal of Medicine offers an explanation why gadolinium based MRI contrast agents may cause Nephrogenic Systemic Fibrosis (NSF) in those with kidney insufficiencies.  NSF has been directly linked to the use of gadolinium, and it has devastating consequences for those who develop the condition.

>>INFORMATION: Gadolinium and Nephrogenic Systemic Fibrosis

Nephrogenic systemic fibrosis (NSF), previously known as nephrogenic fibrosing dermopathy (NFD), is a rare disorder which is associated with the development of fibrosis, or scarring, throughout the body.  It results in a hardening and thickening of the skin which can severely limit mobility of the body, and it can also impact internal tissues.  There is no known cure for NSF and in some cases it progresses rapidly.  Those who develop nephrogenic systemic fibrosis often require the use of a wheelchair and in many cases it contributes to death.

NSF is only known to occur in those with kidney insufficiencies who receive a gadolinium-based contrast agent during an MRI (magnetic resonance imaging) or MRA (magnetic resonance angiography).  Gadolinium is a paramagnetic metal, which is administered as a chelate designed to protect the body from toxic free gadolinium. 

In a letter to the editors of the New England Journal of Medicine, researchers from the University of Arkansas for Medical Sciences indicate that those with kidney insufficiencies may be more susceptible to iron mobilization, which can cause the gadolinium to separate from its chelate leading to NSF.

Data reviewed by the researchers suggests that exposure to gadolinium-based contrasts, such as Omniscan, could substantially decrease total iron-binding capacity and increase iron mobilization.  The iron mobilization may lead to the break down of the chelate, and release the free gadolinium which could cause inflammation and injury to the body’s tissues.  Prior studies of those diagnosed with NSF have shown the presence of gadolinium and iron in biopsy samples of the skin.

NEPHROGENIC SYSTEMIC FIBROSIS LAWSUITS

The lawyers at Saiontz & Kirk, P.A. are investigating Nephrogenic Systemic Fibrosis lawsuits for individuals who have been diagnosed with the condition or have symptoms of NSF.  The manufacturers of gadolinium based contrast agents failed to properly test the impact of their contrast on those with kidney problems and provided insufficient warnings to those receiving the contrast.  As a result of the manufacturers’ negligent conduct, thousands of individuals were not provided an opportunity to reduce the risk of NSF, and now suffer from this devastating condition.

If you, a friend or family member have been diagnosed with NSF or believe you may be suffering from the condition, request a free MRI lawsuit evaluation.