Voltaren Gel Liver Problems

Harvey Kirk

By Harvey Kirk
Posted December 8, 2009


The arthritis topical treatment Voltaren Gel may cause liver problems, according to a new warning required by the FDA. Postmarketing reports suggest that users of Voltaren Gel could face an increased risk of liver damage, the need for a liver transplant or death.

>>FDA LINK: Voltaren Gel Liver Side Effects Warning

In a statement posted on the FDA MedWatch site Friday, new warnings will be added to the non-steroidal anti-inflammatory topical drug, which is indicated for relief of pain of osteoarthritis of joints in the knees and hands. Information will be added about the potential for elevation in liver function tests during treatment with Voltaren Gel.

According to the FDA statement directed to rheumatologists and pharmacists:

In postmarketing reports, cases of drug-induced hepatotoxicity have been reported in the first month but can occur at any time during treatment with diclofenac. Postmarketing surveillance has reported cases of severe hepatic reactions, including liver necrosis, jaundice, fulminant hepatitis with and without jaundice, and liver failure. Some of these reported cases resulted in fatalities or liver transplantation.

In a letter sent to healthcare professionals, Novartis Consumer Health and Endo Pharmaceuticals, the makers of Voltaren Gel, recommended that doctors monitor patients within 4 to 8 weeks after starting treatment, but indicated that severe liver reactions can occur at any time during treatment.

Potential warning signs of Voltaren liver problems could include:

  • Nausea
  • Fatigue
  • Lethargy
  • Diarrhea
  • Jaundice
  • Right Upper Quadrant Tenderness
  • Flu-Like Symptoms


The product liability lawyers at Saiontz & Kirk, P.A. are evaluating the new information provided by the FDA and drug maker to evaluate whether users diagnosed with liver failure may be entitled to compensation through a Voltaren Gel lawsuit. To review a potential case for yourself, a friend or family member who has experienced liver damage, required a liver transplant or died as a result of liver problems, request a free consultation and claim evaluation.

6 Comments • Add Your Comments

  • karen says:

    I had severe rash blistering of the skin in places where voltaren was never applied severe infections surgery neck pain body aches sore throat cough mouth blisters and rash. I have been suffering for one year now with this drug. I stopped it one year ago. I only took the gel for about 2.5 weeks when I woke up one morning to a foot, where the gel was never applied, that was blown up and blistering.

    Posted on August 4, 2015 at 1:17 am

  • Jearline says:

    I was using the gel on my knee and was talking the pills as well which caused my throat to close, and damaged my stomach. I am being treated for stomach problems due to the damage from the medicine. Because of stomach damage I am only able to eat one meal a day with comfort, anything else has to be liquid or a snack size.

    Posted on May 21, 2016 at 12:28 pm

  • John says:

    Prescribed by VA.i have already cheonic hep C. For 30 yrs..am in extreme pain in leg’s a and hip. Due to Aseptic Necrosis of hip. Health getting worse since I started taking. They have me about 10 tubes.I also have coronary artery disease.

    Posted on November 7, 2018 at 3:15 pm

  • Elaine says:

    It also cause chronic kidney disease ! So please call me at 504-264-0033! Im schedule to have tests on my liver very soon!

    Posted on February 19, 2020 at 3:19 pm

  • Belinda says:

    I have been using the Gel for over 2 years. I have suddenly been diagnosed with Liver Cirrhosis. I do not drink. I just started looking at the different medications I used and see that the gel was associated with Liver issues.

    Posted on December 17, 2021 at 4:47 pm

  • VICKI says:

    I have been using it on my foot for plantar faciaitis, and there is a definate rise in my liver enzymes, having been in recovery from Hep C for 15 years.

    Posted on August 14, 2023 at 2:44 pm

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